Brinzolamide
Brinzolamide is a carbonic anhydrase II inhibitor primarily used in ophthalmic formulations to treat conditions such as primary and secondary open-angle glaucoma and ocular hypertension.
- CAS Number: 138890-62-7
- Molecular Formula: C₁₂H₂₁N₃O₅S₃
- Molecular Weight: 383.51 g/mol (or 383.496 g/mol as per some sources)
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in water and organic solvents, facilitating its formulation into 1% ophthalmic drops (e.g., Azopt®).
- Mechanism of Action: By inhibiting睫状体 (ciliary body) carbonic anhydrase, it reduces aqueous humor production, thereby lowering intraocular pressure.
- Therapeutic Use: Administered as 1% eye drops, 1 drop 2-3 times daily, often used as an alternative to β-blockers or in combination therapy.
- Storage and Handling: Requires protection from light and moisture, with a recommended storage temperature of -20°C (for long-term stability) or 2-8°C (for short-term use).
- Safety Considerations: Contraindicated in patients with sulfonamide allergies or severe hepatic/renal impairment. Common adverse reactions include transient blurred vision, burning sensation, and bitter taste.
描述
rinzolamide (CAS: 138890-62-7) is a high-purity carbonic anhydrase inhibitor (molecular formula: C₁₂H₂₁N₃O₅S₃) used as an API for glaucoma treatment. It selectively inhibits carbonic anhydrase II in the ciliary body, reducing aqueous humor production to lower intraocular pressure (IOP)4. This white crystalline powder (99.9% purity) is marketed as eye drops (e.g., Azopt®) for open-angle glaucoma and ocular hypertension, often as an alternative to β-blockers15. Key properties include high selectivity for ocular tissue (minimizing systemic side effects) and stability under 2–8°C storage24. Adverse effects may include bitter taste (5–10%) or transient ocular burning。
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