Brimonidine tartrate
CAS Number: 70359-46-5 (a widely recognized identifier for this compound).
Molecular Formula: C₁₅H₁₆BrN₅O₆, indicating its structure contains bromine, nitrogen, and oxygen atoms in addition to carbon and hydrogen.
Molecular Weight: 442.22 g/mol, reflecting its relatively complex molecular structure.
Appearance: Off-white to pale-yellow powder, which may exhibit a slight greenish-yellow tint in solution (e.g., in 0.2% ophthalmic formulations).
Solubility: Soluble in water (0.6 mg/mL at pH 7.7) and product vehicles (1.4 mg/mL), enabling its use in aqueous ophthalmic solutions.
pH and Osmolality: In solution, it has a pH range of 5.8–6.6 (for 0.2% formulation) or 7.4–8.0 (for 0.1% formulation), with an osmolality of 250–350 mOsmol/kg, ensuring compatibility with ocular tissues.
Purity: Typically ≥98% or ≥99%, depending on the supplier and intended use (pharmaceutical-grade material adheres to strict quality standards).
描述
Brimonidine tartrate (CAS: 70359-46-5) is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with the molecular formula C₁₅H₁₆BrN₅O₆ (molecular weight: 442.22). It appears as a white to off-white or pale yellow powder and is primarily used as a selective α₂-adrenergic receptor agonist for treating open-angle glaucoma and ocular hypertension by reducing intraocular pressure (IOP). The compound exhibits high selectivity for α₂ receptors (α₂/α₁ affinity ratio >1000:1), minimizing systemic side effects like sedation or hypotension.
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