Phenylephrine HCL

Phenylephrine HCl

molecular formula: ‌C₉H₁₄ClNO₂

CAS: ‌61-76-7

Appearance‌: White or nearly white crystalline solid ‌12

Melting point‌: 143–145°C (lit.) ‌2

Solubility‌: ≥10 g/100 mL in water (21°C) ‌2

Storage‌: Desiccate at room temperature (RT) or 2–8°C ‌23

Purity‌: ≥98% (pharmaceutical grade)

描述

Phenylephrine HCl‌ (CAS: ‌61-76-7‌) is a ‌white crystalline powder‌ with the molecular formula ‌C₉H₁₄ClNO₂‌ (molecular weight: ‌203.67‌). As a ‌selective α₁-adrenergic agonist‌, it is widely used as a ‌vasoconstrictor‌ in pharmaceuticals, primarily for treating ‌nasal congestion‌ (decongestant) and ‌hypotension‌. Its mechanism involves binding to α₁-receptors, inducing vasoconstriction. The compound is ‌water-soluble‌ (≥10 g/100 mL at 21°C) and stable under dry conditions. Pharmaceutical-grade phenylephrine HCl typically exhibits ‌≥98% purity‌, with applications extending to ‌ophthalmic solutions‌ (pupil dilation) and ‌injectable formulations‌. Also known as ‌L-Phenylephrine hydrochloride‌, it is recognized as an ‌R-(-)-enantiomer‌ (optical rotation: [α]²⁴ᴅ = -45.5°). Storage recommendations include ‌desiccated environments‌ at ‌room temperature or 2–8°C‌。

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